The attack was perpetrated in the municipality of Mezzeh, a densely populated area where several schools and markets are located.
Firefighters and ambulances rushed to the scene amid reports of deaths and injuries.
Prensa Latina confirmed a fire in an apartment in a 14-story building, in addition to material damage to three floors and to cars parked at the site.
Israel has intensified its military actions against targets in Syrian territory, where the Ministry of Defense reported three deaths in the aftermath of an Israeli air strike on a building in the same neighborhood of Mezzeh on October 2.
On Sunday, Syrian air defense batteries opened fire to shoot down Israeli missiles fired at Homs province, some 200 kilometers north of the capital.
Hours before the raid, three cars laden with medical and relief supplies were attacked by Israel in the industrial town of Hassieh, some 120 kilometers north of Damascus.
Last Friday, the highway connecting Damascus and Beirut also came under fire, and three were killed in an air strike on a building in the Syrian capital on Thursday.
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