Both women, who carried a two-month-old baby, were planning to board a commercial flight to Paris (France).
The foreigners entered Brazil by land in Tabatinga, a border city in the Amazon with Letícia, in the neighboring country.
On national territory, they collected the suitcases with false bottoms that stored the drugs, according to the PF in a statement.
The Law and Order Guarantee operation had the support of the Brazilian Air Force and the National Security Force for the custody and transfer of the prisoners to the PF Superintendency.
The suspects will respond for transnational drug trafficking, the penalty for which can reach up to 15 years in prison.
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