Specialists have shown that a natural substance called ¨hyaluronic acid¨, which is used in cosmetics and injections for osteoarthritis, is the key molecule that manages this fundamental interaction.

“When muscles get damaged, it´s quite important for immune cells to quickly enter the tissue and remove the damage before stem cells begin to repair,” said Dr. Jeffrey Dilworth, senior scientists at the Ottawa Hospital and professor at the University of Ottawa and senior author on the study.

“Our study shows that muscle stem cells are primed to start repair right away, but the immune cells keep the stem cells in a resting state while they finish the cleanup job,” Dr. Dilworth pointed out.

After about 40 hours, once the cleanup job is finished, an internal alarm goes off in the muscle stem cells that allows them to wake up and start repair.”

Dr. Dilworth and his team identified hyaluronic acid as the key ingredient in this internal alarm clock that tells muscle stem cells when to wake up.

Once the coating gets thick enough, it blocks the sleep signal from the immune cells and causes the muscle stem cells to wake up.

Using mouse and human tissues, Dr. Dilworth and his team also discovered how muscle stem cells control the production of hyaluronic acid using epigenetic marks on the Has2 gene.

“Interestingly, aging is associated with chronic inflammation, muscle weakness and a reduced ability of muscle stem cells to wake up and repair damage,” said lead author Dr. Kiran Nakka, a research associate with Dr. Dilworth who conducted this research as part of his postdoctoral studies. “If we could find a way to enhance hyaluronic acid production in the muscle stem cells of older people it might help with muscle repair.”

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